Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab3940 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 43 kDa.Can be blocked with Human Neuro D4 peptide (ab22971).

Target

  • Function
    May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
  • Sequence similarities
    Belongs to the requiem/DPF family.
    Contains 2 PHD-type zinc fingers.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • BAF45B antibody
    • BRG1-associated factor 45B antibody
    • D4 antibody
    • D4 zinc and double PHD fingers family 1 antibody
    • DPF1 antibody
    • DPF1_HUMAN antibody
    • NEUD4 antibody
    • Neuro d4 homolog antibody
    • Zinc and double PHD fingers family 1 antibody
    • Zinc finger protein neuro-d4 antibody
    see all

Images

  • Anti-Neuro D4 antibody (ab3940) at 1 µg/ml + Human Brain (Cerebellum) lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 43 kDa
    Observed band size : 35 kDa (why is the actual band size different from the predicted?)

References

ab3940 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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