Anti-NeuroD1 antibody - N-terminal (ab227968)

Overview

  • Product name
    Anti-NeuroD1 antibody - N-terminal
    See all NeuroD1 primary antibodies
  • Description
    Rabbit polyclonal to NeuroD1 - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow, Xenopus laevis
  • Immunogen

    Synthetic peptide within Human NeuroD1 (N terminal). The exact sequence is proprietary. Carrier-protein conjugated.
    Database link: Q13562

  • Positive control
    • WB: NTERA-2 cl.D1 [NT2/D1], U-87 MG and SK-N-SH whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab227968 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 40 kDa.

Target

  • Function
    Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
  • Involvement in disease
    Defects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • Sequence similarities
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • Post-translational
    modifications
    Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
    • Alternative names
      • atonal antibody
      • basic helix loop helix transcription factor antibody
      • BETA 2 antibody
      • Beta cell E box transactivator 2 antibody
      • BETA2 antibody
      • BHF 1 antibody
      • BHF1 antibody
      • bHLHa3 antibody
      • class A basic helix loop helix protein 3 antibody
      • Class A basic helix-loop-helix protein 3 antibody
      • MODY 6 antibody
      • MODY6 antibody
      • NDF1_HUMAN antibody
      • NeuroD antibody
      • NeuroD1 antibody
      • Neurogenic differentiation 1 antibody
      • Neurogenic differentiation factor 1 antibody
      • neurogenic helix loop helix protein NEUROD antibody
      • Neuronal differentiation 1 antibody
      see all

    Images

    • All lanes : Anti-NeuroD1 antibody - N-terminal (ab227968) at 1/1000 dilution

      Lane 1 : NTERA-2 cl.D1 [NT2/D1] (human malignant pluripotent embryonic carcinoma cell line) whole cell lysate
      Lane 2 : U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell lysate
      Lane 3 : SK-N-AS (human neuroblastoma cell line) whole cell lysate

      Lysates/proteins at 30 µg per lane.

      Predicted band size: 40 kDa



      10% SDS-PAGE gel.

    References

    ab227968 has not yet been referenced specifically in any publications.

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