Application notesThis antibody gave a positive result in ELISA against the immunizing peptide. Antibody detection limit dilution 1:4,000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionNeuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses.
Tissue specificityExpressed in the blood vessel walls (at protein level).
Sequence similaritiesBelongs to the type-B carboxylesterase/lipase family.
Cellular localizationCell membrane. Cell junction > synapse. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities.