Overview

  • Product nameAnti-Neuroligin 3 antibody
    See all Neuroligin 3 primary antibodies
  • Description
    Mouse monoclonal to Neuroligin 3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: PRVRDHYRAT KVAFWKHLVP HLYNLHDMFH YTSTTTKVPP PDTTHSSHIT RRPNGKTWST KRPAISPAYS NENAQGSWNG DQDAGPLLVE NPRDYSTELS , corresponding to amino acids 590-690 of Human Neuroligin 3

Properties

Applications

Our Abpromise guarantee covers the use of ab57375 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
    • Tissue specificityExpressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.
    • Involvement in diseaseAutism, X-linked 1 (AUTSX1) [MIM:300425]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
      X-linked Asperger syndrome 1 (ASPGX1) [MIM:300494]: Considered to be a form of childhood autism. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    • Sequence similaritiesBelongs to the type-B carboxylesterase/lipase family.
    • Cellular localizationCell membrane. Cell junction > synapse. Detected at both glutamatergic and GABAergic synapses.
    • Information by UniProt
    • Database links
    • Alternative names
      • Gliotactin homolog antibody
      • HNL3 antibody
      • Neuroligin-3 antibody
      • Nlgn3 antibody
      • NLGN3_HUMAN antibody
      see all

    Anti-Neuroligin 3 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57375 Neuroligin 3 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-Neuroligin 3 antibody (ab57375)

    ab57375 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"