Recombinant
RabMAb

Anti-Neuroligin 3 antibody [EPR16158] (ab192880)

Overview

  • Product name
    Anti-Neuroligin 3 antibody [EPR16158]
    See all Neuroligin 3 primary antibodies
  • Description
    Rabbit monoclonal [EPR16158] to Neuroligin 3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Neuroligin 3 aa 150-250. The exact sequence is proprietary.
    Database link: Q9NZ94

  • Positive control
    • Human hippocamus and Human pancreas lysates.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab192880 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Detects a band of approximately 94 kDa (predicted molecular weight: 94 kDa).

Target

  • Function
    Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
  • Tissue specificity
    Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.
  • Involvement in disease
    Autism, X-linked 1 (AUTSX1) [MIM:300425]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    X-linked Asperger syndrome 1 (ASPGX1) [MIM:300494]: Considered to be a form of childhood autism. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Sequence similarities
    Belongs to the type-B carboxylesterase/lipase family.
  • Cellular localization
    Cell membrane. Cell junction > synapse. Detected at both glutamatergic and GABAergic synapses.
  • Information by UniProt
  • Database links
  • Alternative names
    • Gliotactin homolog antibody
    • HNL3 antibody
    • Neuroligin-3 antibody
    • Nlgn3 antibody
    • NLGN3_HUMAN antibody
    see all

Images

  • All lanes : Anti-Neuroligin 3 antibody [EPR16158] (ab192880) at 1/2000 dilution

    Lane 1 : Human hippocamus lysate
    Lane 2 : Human pancreas lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size : 94 kDa
    Observed band size : 94 kDa

References

This product has been referenced in:
  • Peng J  et al. TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System. Front Pharmacol 8:486 (2017). WB ; Mouse . Read more (PubMed: 28798687) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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