All tags neuroscience Conformation-specific antibodies for Alzheimer's research

Conformation-specific antibodies for Alzheimer's research

In collaboration with Professor Charles Glabe, we developed rabbit monoclonal antibodies against Aß 1–42 fibrils that can distinguish conformational variation in amyloid structures.

In Alzheimer's disease, Aß peptides aggregate to form neurotoxic plaques. These plaques exhibit diverse conformations resulting in structural variants with distinct pathologies. Learn more about conformational variation of Aß.

Browse all conformation-specific antibodies for Alzheimer's disease

Antibody reactivity in human and mouse Alzheimer's disease brain

Antibody nameAntibody IDHuman Alzheimer's brain specificity shown by IHC**Alzheimer's mouse model* brain specificity shown by IHC**
Anti-amyloid fibril antibody [mOC22] - conformation-specificab205339Frontal cortex plaquesLayer V cortical and CA1 pyramidal neurons
Anti-beta amyloid 1-42 antibody [mOC23] - conformation specific ab205340Subset of frontal cortex plaquesHippocampal plaques

Anti-beta amyloid 1-42 antibody [mOC31] - conformation-specific

ab201059Vascular amyloid depositsN/A
Anti-beta amyloid 1-4 antibody [mOC64] - conformation-specificab201060Frontal cortex plaquesN/A
Anti-amyloid fibril antibody [mOC78] - conformation specificab205341Intracellular/nuclear, frontal cortex plaquesLayer V cortical neurons
Anti-amyloid fibril antibody [mOC87] - conformation-specificab201062Frontal cortex plaquesLayer V cortical neurons (intracellular deposits)
Anti-beta amyloid 1-42 antibody [mOC98] - conformation-specificab201061Frontal cortex plaquesLayer V cortical neurons (intracellular deposits)
Anti-amyloid fibril antibody [mOC116] - conformation specificab205342Frontal cortex plaquesLayer V cortical neurons, ​hippocampal plaques​

*14 month-old 3xTg-AD mouse model of Alzheimer's disease

** IHC shown in Hatami et al. 2014

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