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Dopaminergic neurons produce dopamine, a neurotransmitter with roles in neurological functions such as mood and reward. Progressive loss of dopaminergic neurons is the cause of many of the motor symptoms associated with Parkinson’s disease.
Tyrosine hydroxylase (TH)
An enzyme that converts L-tyrosine to L-3,4-dihydroxyphelylalanine (L-DOPA), which is a dopamine precursor.
Rat brain sections stained with anti-tyrosine hydroxylase (ab75875).
Tyrosine hydroxylase inhibitors and activators
|3-Iodo-L-tyrosine (MIT) (ab144773)||Tyrosine hydroxylase inhibitor. Inhibits dopamine synthesis. Stimulates prolactin secretion.|
|O,α-Dimethyl-DL-tyrosine (ab144755)||Tyrosine hydroxylase inhibitor. Potential modulator of dopamine synthesis.|
|3-Iodo-L-tyrosine (MIT) (ab144773)||Tyrosine hydroxylase activator. Shows neuroprotective and cardioprotective effects in vivo.|
Dopamine transporter (DAT)
A transmembrane transporter that controls the re-uptake of extracellular dopamine into presynaptic neurons.
Mouse substantia nigra sections stained with anti-dopamine transporter (ab128848).
Dopamine transporter inhibitors
|Clomipramine hydrochloride (ab143213)||Selective α1-adrenoceptor antagonist. DAT blocker.|
|Benztropine mesylate (ab143332)||Potent DAT inhibitor. Selective M1 receptor antagonist.|
|Bupropion hydrochloride (ab120534)||Non-selective dopamine and norepinephrine transporter (DAT/NET) inhibitor.|
|GBR 12909 dihydrochloride (ab120607)||Potent, selective dopamine reuptake inhibitor.|
A G-protein regulated potassium channel expressed within certain dopaminergic neurons of the substantia nigra.
Mouse substantia nigra tissue sections stained with anti-GIRK2 (ab65096).
GIRK2 inhibitors and activators
|ML297 (VU0456810) (ab143564)||Potent, selective GIRK activator.|
|Ifenprodil hemitartrate (ab120111)||Reversible inhibitor of GIRK activity.|
|Pimozide (ab142135)||GIRK inhibitor at nanomolar concentration.|