All tags Neuroscience GABAergic neuron markers

GABAergic neuron markers

Commonly used markers for GABAergic neurons

GABAergic neurons generate gamma aminobutyric acid (GABA), one of the two inhibitory neurotransmitters in the central nervous system (CNS).


GABA transporter 1 (GAT1)
A transporter on the cell membrane that moves GABA into the cell.

Mouse brain tissue sections stained with anti-GABA transporter 1 (ab64645).

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GAT1 inhibitors

ProductActivity
NNC 711 (ab120364)​​Potent, selective GAT1 inhibitor
Potent, selective GAT-1 inhibitor
Tiagabine hydrochloride (ab120237)Selective GAT1 inhibitor



GABAB receptor 1 and 2

GABAB receptors are metabotropic transmembrane receptors for GABA that are linked via G-proteins to potassium channels. GABAB receptor 1 and GABAB receptor 2 assemble as heterodimers in neuronal membranes.

Rat brain (hippocampus) stained with anti-GABA B receptor 1 (red) (ab55051).

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GABAB receptor modulators

ProductActivity
Saclofen (ab120327)Selective GABAB receptor agonist
(R)-Baclofen (ab120325)GABAB receptor agonist
CGP 35348 (ab120167)GABAB receptor agonist
CGP 7930 (ab120492)Positive GABAB receptor allosteric modulator
GS 39783 (ab120320)Novel GABAB positive allosteric modulator



GAD65
The 65 kDa isomorph of glutamate decarboxylase that catalyzes the formation of GABA from glutamate.

Rat cerebellar cortex labeled with anti-GAD65 (ab26113).

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GAD67
The 67 kDa isomorph of glutamate decarboxylase. Unlike GAD65, which is also expressed in the pancreas, GAD67 is CNS-specific.

Mouse cerebellum sections stained with anti-GAD67 (ab26116).

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References 

  • Adams, C. L. & Lawrence, A. J. CGP7930: a positive allosteric modulator of the GABAB receptor. CNS Drug Rev. 13, 308–16 (2007).
  • Bettler, B., Kaupmann, K., Mosbacher, J. & Gassmann, M. Molecular structure and physiological functions of GABA(B) receptors. Physiol. Rev. 84, 835–67 (2004).
  • Bráz, J. M. et al. Forebrain GABAergic Neuron Precursors Integrate into Adult Spinal Cord and Reduce Injury-Induced Neuropathic Pain. Neuron 74, 663–675 (2012).
  • Misgeld, U., Bijak, M. & Jarolimek, W. A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system. Prog. Neurobiol. 46, 423–62 (1995).
  • Obrietan, K. & van den Pol, A. N. GABAB receptor-mediated inhibition of GABAA receptor calcium elevations in developing hypothalamic neurons. J. Neurophysiol. 79, 1360–70 (1998).
  • Rey, A. A., Purrio, M., Viveros, M.-P. & Lutz, B. Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABAB Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission. Neuropsychopharmacology 37, 2624–2634 (2012).
  • Volk, D. W., Sampson, A. R., Zhang, Y., Edelson, J. R. & Lewis, D. A. Cortical GABA markers identify a molecular subtype of psychotic and bipolar disorders. Psychol. Med. 1–12 (2016). 
  • Zhou, Y. & Danbolt, N. C. GABA and Glutamate Transporters in Brain. Front. Endocrinol. (Lausanne). 4, 165 (2013).


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