All tags neuroscience Mature neuron markers

MAP2 antibody (ab5392)

Mature neuron markers

A quick reference guide to mature neuron markers

Mature neurons are terminally differentiated and are no longer able to divide. Their purpose is to receive, process, and transfer information in the central and peripheral nervous systems. 

NeuN
An RNA binding protein that is highly specific for post-mitotic neurons, however, the following cell types do not express NeuN:

  • ​Golgi cells​
  • Purkinje cells
  • Olfactory bulb mitral cells
  • Retinal photoreceptor cells
  • Inferior olivary and dentate nucleus neurons
  • Sympathetic ganglion cells

Mouse cerebrum sections stained with anti-NeuN (green) (ab177487).

Browse all NeuN antibodies​​

Read about the advantages of our NeuN recombinant rabbit monoclonal antibody (ab177487)


MAP2

MAP2
A neuron-specific protein that promotes assembly and stability of the microtubule network.

Mouse primary neurons stained with anti-MAP2 (green) (ab5392).

​​​Browse all MAP2 antibodies​


160 kDa Neurofilament medium
Major intermediate filament found in neurons.

Rat cerebellum sections stained using ​anti-160 kDa neurofilament medium (ab64300).

Browse all 160 kDa neurofilament medium antibodies


200 kDa Neurofilament heavy
Major intermediate filament found in neurons.

Rat brain sections stained using anti-200 kDa neurofilament heavy (red) (ab8135).

Browse all 200 kDa neurofilament Heavy antibodies


Synaptophysin
Synaptic vesicle protein that regulates vesicle endocytosis in neurons.

Human iPS cell-derived neurons stained with anti-synaptophysin (green) (ab32127).

Browse all synaptophysin antibodies


PSD95
Synaptic protein that associates with receptors and the cytoskeleton.

Rat cerebellum sections stained with anti-PSD95 (ab18258).

Browse PSD95 antibodies



References

  • El-Husseini, A. E. et al. PSD-95 involvement in maturation of excitatory synapses. Science 290, 1364–8 (2000).
    Kwon, S. E. & Chapman, E. R. Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons. Neuron 70, 847–54 (2011).
    Mullen, R. J., Buck, C. R. & Smith, A. M. NeuN, a neuronal specific nuclear protein in vertebrates. Development 116, 201–211 (1992).
    Soltani, M. H. et al. Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma. Am. J. Pathol. 166, 1841–1850 (2005).
    Trojanowski, J. Q., Walkenstein, N. & Lee, V. M. Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies. J. Neurosci. 6, 650–660 (1986).
    Yuan, a., Rao, M. V., Veeranna & Nixon, R. a. Neurofilaments at a glance. J. Cell Sci. 125, 3257–3263 (2012).
    El-Husseini, A. E. et al. PSD-95 involvement in maturation of excitatory synapses. Science 290, 1364–8 (2000).
  • Kwon, S. E. & Chapman, E. R. Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons. Neuron 70, 847–54 (2011).
  • Mullen, R. J., Buck, C. R. & Smith, A. M. NeuN, a neuronal specific nuclear protein in vertebrates. Development 116, 201–211 (1992).
  • Soltani, M. H. et al. Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma. Am. J. Pathol. 166, 1841–1850 (2005).
  • Trojanowski, J. Q., Walkenstein, N. & Lee, V. M. Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies. J. Neurosci. 6, 650–660 (1986).
  • Yuan, a., Rao, M. V., Veeranna & Nixon, R. a. Neurofilaments at a glance. J. Cell Sci. 125, 3257–3263 (2012).


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