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Neuroinflammation in neurodegenerative diseases

Get to the root cause of neurodegeneration with a comprehensive range of neuroinflammation research tools to detect glia, aggregated proteins and proinflammatory mediators in Alzheimer's and Parkinson's diseases.


Label astrocytes and microglia

Activated microglia and astrocytes are present in nearly all neurodegenerative diseases inlcuding Alzheimer's and Parkinson's1. Easily label microglia and astrocytes with a versatile range of conjugated and unconjugated glial markers. Check out the guides below to ensure you’re using the best markers for your experiments.

Anti-Tmem119 antibody [28-3] – microglial marker (ab209064)
Immunohistochemistry (IHC-Fr-frozen sections) of mouse corpus callosum stained using anti-tmem119 (ab209064). Tmem119 is a highly specific cell-surface marker of microglia that is not expressed by macrophages or other immune or neural cell types2. View all tmem119 antibodies.


Study aggregated and misfolded proteins

There is a complex array of interactions between misfolded proteins and neuroinflammation3. Enhance your study of misfolded proteins with near-infrared (NIRF) probes and antibodies against post-translational modification and conformational variants. Take a look at our recommendations below.


Protein of interestRecommended products
Amyloid beta (Aß)

Detect structural variants of Aß with conformation-specific amyloid antibodies .

Image soluble and insoluble Aß in real-time with cell permeable and non-toxic near infrared Aß probes.

Easily induce neurotoxicity and neurodegeneration with an Aß peptide.

Alpha synuclein

Specifically detect aggregated alpha  synuclein with an alpha synuclein filament antibody.

Manipulate  Lewy body formation with active alpha-synuclein monomers and aggregates.

Tau

Easily label total tau with anti-Tau [TAU5], which binds to the unmodified proline rich domain (PRD).

Detect posttranslational modifications of tau with a comprehensive range of phospho tau antibodies.


Detect pro-inflammatory mediators

A chronic inflammatory environment in the brain is a hallmark of neurodegenerative diseases such as Alzheimer’s and Parkinson’s 4,5. Easily dissect the role of pro-inflammatory mediators with fast SimpleStep ELISA® kits, matched antibody pairs (MAPs), or take a multiplex approach with FirePlex® immunoassays.

Single-plex detection
Get results in just 90 minutes with  SimpleStep ELISA kits, without compromising on performance. Learn more about SimpleStep ELISA.

Product highlights:
Mouse IL-1 beta ELISA Kit (ab197742)
Human IL-1 beta ELISA Kit (ab214025)
Human TNF alpha ELISA Kit (ab181421)
Mouse TNF alpha ELISA Kit (ab208348)
Browse all SimpleStep ELISA kits

Multiplex detection
FirePlex® immunoassays feature fully customizable multiplex panels that allow you to analyze up to 75 analytes per well. Build your own panel or select a pre-designed panel for either human or mouse samples. Find out more about Fireplex immunoassays.

Need us to analyze your samples for you? Learn about our cytokine profiling services.


References

1.    Doty, K. R., Guillot-Sestier, M.-V. & Town, T. The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive? BRAIN Res. 1617, 155–173 (2015).
2.    Bennetta, M. L. et al. New tools for studying microglia in the mouse and human CNS. Pnas 1525528113- (2016). doi:10.1073/pnas.1525528113
3.    Sweeney, P. et al. Protein misfolding in neurodegenerative diseases: implications and strategies. Transl. Neurodegener. 6, 6 (2017).
4.    Cameron, B. & Landreth, G. E. Inflammation, microglia, and Alzheimer’s disease. Neurobiol. Dis. 37, 503–9 (2010).
5.    Wang, Q., Liu, Y. & Zhou, J. Neuroinflammation in Parkinson’s


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