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A guide to Schwann cell markers throughout development.
Schwann cells are the myelin-producing cells of the peripheral nervous system where they form the myelin sheath around axons. Their function is equivalent to that of oligodendrocytes in the central nervous system.
Schwann cell markers throughout development
Schwann cell stage Suggested markers Schwann cell precursor SOX10, GAP43, BLBP, MPZ, Dhh, P75NTR Myelinating Schwann cells SOX10, S100, EGR2, MBP, MPZ Non myelinating Schwann cells SOX10, GAP43, S100, NCAM, P75NTR
A glycoprotein involved in cell adhesion, expressed by non-myelinating Schwann cells.
Zebrafish embryo stained with anti-NCAM (green) ( ab9272).
Browse all NCAM antibodies
The p75 NGF receptor (otherwise known as p75 neurotrophin receptor or p75NTR binds nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) as well as neurotrophins 3 and 4.
PC12 cells stained with anti-p75 NGF antibody ( ab52987).
Browse all P75NTR antibodies
References Dechant, G. & Barde, Y.-A. The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system. Nat. Neurosci. 5, 1131–1136 (2002). Jessen, K. R. & Mirsky, R. The origin and development of glial cells in peripheral nerves. Nat. Rev. Neurosci. 6, 671–82 (2005). Jessen, K. R., Mirsky, R. & Lloyd, A. C. Schwann Cells: Development and Role in Nerve Repair. Cold Spring Harb. Perspect. Biol. 7, a020487 (2015). Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I. & Wegner, M. Sox10, a novel transcriptional modulator in glial cells. J. Neurosci. 18, 237–250 (1998). Liu, Z. et al. Specific marker expression and cell state of Schwann cells during culture in vitro. PLoS One 10, e0123278 (2015).