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Untangle tau

Study tau from every angle with a comprehensive array of research tools to provide new insights into tau pathology. From aggregation inhibitors to kits and antibodies, find everything you need to untangle tau, in one place.

​​​Figure 1:  Formation of neurofibrillary tangles (NFTs) by the tau protein in tauopathies such as Alzheimer’s disease. Under pathological conditions tau becomes hyperphosphorylated and detaches from microtubules. Phosphorylated tau then aggregates to form paired helical filaments (PHFs) and neurofibrillary tangles (NFTs). 


Total tau detection

Tau is found in soluble form in the normal brain but in AD, becomes aggregated and insoluble. Easily detect total tau with a BSA and azide-free antibody, an antibody panel, or an ELISA kit from the table below.
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Reagent

Recommended product

abID

Total tau antibody

Anti-Tau antibody [TAU-5] - BSA and Azide free

ab80579

Tau antibody panel

Tau Research Antibody Panel

ab226492

ELISA

Human Tau ELISA Kit

ab210972

Note: Studying insoluble tau can be problematic, consider using detergents such as RIPA and Sarkosyl1.


Tau phosphorylation

Tau function is governed by phosphorylation, which becomes dysregulated during pathology, resulting in mislocalization, aggregation, and neuronal death. Effortlessly study all aspects of tau phosphorylation with antibodies against different post-translationally modified sites.

Phosphorylation site

Recommended product

abID

Serine 202 and threonine 205

Anti-Tau (phospho S202 + T205) antibody [EPR20390]

ab210703

Threonine 231

Anti-Tau (phospho T231) antibody [EPR2488]

ab151559

Serine 262

Anti-Tau (phospho S262) antibody

ab64193

Serine 396

Anti-Tau (phospho S396) antibody [EPR2731]

ab109390

Serine 422

Anti-Tau (phospho S422) antibody [EPR2866]

ab79415

Browse all antibodies to detect phosphorylated tau.

If you need multiple phosphorylated tau antibodies, try our Tau antibody panel (ab226492).


Tau aggregation inhibitors

The presence of aggregated tau corresponds with pathology in diseases such as Alzheimer’s. Effectively inhibit the formation of neurofibrillary tangles with a potent tau aggregation inhibitor.


Small molecule

Activity

abID

TRx0237 mesylate (LMTX)

Reduces tau pathology and reverses behavioral impairment in mice2. Active in vitro and in vivo3.

ab223882

AZD2858


Selective GSK-3 inhibitor (IC50 = 68 nM) of tau phosphorylation at the S396 site4.

ab223889

INDY


ATP-competitive Dyrk1A inhibitor capable of reversing tau phosphorylation5.

ab223890

GSK-3β Inhibitor VII


Cell-permeable, non-ATP competitive GSK-3β inhibitor (IC50 = 0.5 µM)6.

ab145937

YM-01 (YM-1)


Allosteric Hsp70 modulator which potently reduces aberrant tau levels (EC50 ~ 0.9 μM)7.

ab146423

Browse all tau inhibitors

Browse microtubule activators and inhibitors


Tau and neuroinflammation

There is a complex interplay between misfolded proteins and neuroinflammation in neurodegenerative disease. Study tau in the context of neuroinflammation with a range of tools to study proinflammatory mediators.


Tool

Recommended product(s)

abID

Mouse and human multiplex cytokine panels

Human Key cytokines (15 plex) Multiplex Immunoassay Kit

Mouse Key cytokines (14 plex) Multiplex Immunoassay Kit

ab213392


ab213396

TNF alpha ELISA kit

Mouse TNF alpha ELISA Kit

ab208348

IL-1 beta ELISA kit

Mouse IL-1 beta ELISA Kit (Interleukin-1 beta)

ab100704

IL-6 ELISA kit

Human IL-6 ELISA Kit (Interleukin-6) High Sensitivity

ab46042

Profile multiple cytokines with a pre-designed panel, or define your own - learn more about Fireplex immunoassays

Get results in 90 minutes - discover the range of SimpleStep ELISA® kits


References

1.        Forest, S. K., Acker, C. M., d’Abramo, C. & Davies, P. Methods for measuring tau pathology in transgenic mouse models. J. Alzheimers. Dis. 33, 463–71 (2013). Read more

2.        Melis, V. et al. Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models. Behav. Pharmacol. 26, 353–368 (2015). Read more

3.        Panza, F. et al. Tau aggregation inhibitors: the future of Alzheimer’s pharmacotherapy? Expert Opin. Pharmacother. 17, 457–461 (2016). Read more

4.        Marsell, R. et al. GSK-3 inhibition by an orally active small molecule increases bone mass in rats. Bone 50, 619–627 (2012). Read more

5.        Ogawa, Y. et al. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat. Commun. 1, 1–9 (2010). Read more

6.        Conde, S. et al. Thienyl and Phenyl α-Halomethyl Ketones: New Inhibitors of Glycogen Synthase Kinase (GSK-3β) from a Library of Compound Searching. (2003). J Med Chem. 46, 4631-3 (2003). Read more

7.        Abisambra, J. et al. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol. Psychiatry 74, 367–374 (2013). Read more



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