Anti-Neuroserpin antibody [1D10] (ab125097)

Overview

  • Product nameAnti-Neuroserpin antibody [1D10]
    See all Neuroserpin primary antibodies
  • Description
    Mouse monoclonal [1D10] to Neuroserpin
  • Tested applicationsSuitable for: Sandwich ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length mature protein, corresponding to amino acids 17-410 of Human Neuroserpin with 26kDa proprietary tag (AAH18043).

  • Positive control
    • HeLa cell lysate;, Hman Brain cortex tissue; recombinant protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab125097 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA Use at an assay dependent concentration.
WB 1/500 - 1/1000. Predicted molecular weight: 46 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionSerine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
  • Tissue specificityPredominantly expressed in the brain.
  • Involvement in diseaseDefects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B) [MIM:604218]. FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin.
  • Sequence similaritiesBelongs to the serpin family.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp781N13156 antibody
    • Neuroserpin antibody
    • NEUS_HUMAN antibody
    • Peptidase inhibitor 12 antibody
    • PI-12 antibody
    • PI12 antibody
    • Protease inhibitor 12 antibody
    • Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1 antibody
    • Serine or cysteine proteinase inhibitor clade I member 1 antibody
    • Serpin I1 antibody
    • Serpin peptidase inhibitor clade I (neuroserpin) member 1 antibody
    • SERPINI1 antibody
    see all

Anti-Neuroserpin antibody [1D10] images

  • Anti-Neuroserpin antibody [1D10] (ab125097) at 1/500 dilution + HeLa cell lysate

    Predicted band size : 46 kDa
  • ab125097, at 5 µg/ml, staining Neuroserpin in Formalin-fixed, Paraffin-embedded Human brain cortex tissue by Immunohistochemistry
  • Using ab125097 as a capture antibody, the detection limit for recombinant proprietary tagged Neuroserpin is approximately 0.3ng/ml.

References for Anti-Neuroserpin antibody [1D10] (ab125097)

ab125097 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"