Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab46773 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: 1/1000 - 1/5000. Predicted molecular weight: 46 kDa. A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionSerine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
    • Tissue specificityPredominantly expressed in the brain.
    • Involvement in diseaseDefects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B) [MIM:604218]. FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin.
    • Sequence similaritiesBelongs to the serpin family.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • CLADE I antibody
      • DKFZp781N13156 antibody
      • MEMBER 1 antibody
      • Neuroserpin antibody
      • NEUS_HUMAN antibody
      • Peptidase inhibitor 12 antibody
      • PI-12 antibody
      • PI12 antibody
      • Protease inhibitor 12 antibody
      • Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1 antibody
      • Serine or cysteine proteinase inhibitor clade I member 1 antibody
      • SERINE PROTEASE INHIBITOR antibody
      • Serpin I1 antibody
      • Serpin peptidase inhibitor clade I (neuroserpin) member 1 antibody
      • SERPINI1 antibody
      see all

    Anti-Neuroserpin antibody images

    • All lanes : Anti-Neuroserpin antibody (ab46773) at 1/1000 dilution

      Lane 1 : Neuroserpin at 0.04 µg
      Lane 2 : Neuroserpin at 0.02 µg


      Predicted band size : 46 kDa

    References for Anti-Neuroserpin antibody (ab46773)

    ab46773 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"