Anti-Neurotrophin 4 antibody (ab6205)

Overview

  • Product name
    Anti-Neurotrophin 4 antibody
    See all Neurotrophin 4 primary antibodies
  • Description
    Rabbit polyclonal to Neurotrophin 4
  • Specificity
    Less than 1% cross reactivity against NGF, BDNF and NT3 by dot blot. Cross reactivity: Known to react with human NT4. Not yet tested against other species.
  • Tested applications
    Suitable for: Dot blot, ELISA, IHC-Fr, Neutralising, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human).

  • General notes
    The concentrations of NT4 are generally very low in most tissues. A good positive control is neonatal testes of rat (Zhang et al, 1999). This antibody has been shown useful for quantitative ELISA, immunohistochemistry of lesioned brain as well as for western blot and inhibition of biological activity

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab6205 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot
ELISA
IHC-Fr
Neutralising
WB
  • Application notes
    Immunohistochemistry: 1-2 ug/ml
    Western Blot: 1-2 ug/ml
    Immunoblot: 1-2 ug/ml
    1 site ELISA: 0.5 ug/ml
    Biological Inhibition: 2-10 ug/ml (ED50)
  • Target

    • Function
      Target-derived survival factor for peripheral sensory sympathetic neurons.
    • Tissue specificity
      Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
    • Involvement in disease
      Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
    • Sequence similarities
      Belongs to the NGF-beta family.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • GLC10 antibody
      • GLC1O antibody
      • Neurotrophic factor 4 antibody
      • Neurotrophic factor 5 antibody
      • Neurotrophin 4 antibody
      • Neurotrophin 4/5 antibody
      • Neurotrophin 5 (neurotrophin 4/5) antibody
      • Neurotrophin 5 antibody
      • Neurotrophin-4 antibody
      • Neurotrophin-5 antibody
      • Neutrophic factor 4 antibody
      • Neutrophic factor 5 antibody
      • NT 4 antibody
      • NT 4/5 antibody
      • NT 5 antibody
      • NT-4 antibody
      • NT-5 antibody
      • NT4 antibody
      • NT4/5 antibody
      • NT4P antibody
      • NT5 antibody
      • NTF4 antibody
      • NTF4_HUMAN antibody
      • NTF5 antibody
      see all

    References for Anti-Neurotrophin 4 antibody (ab6205)

    ab6205 has not yet been referenced specifically in any publications.

    Product Wall

    ab6204 and ab6205 are both suitable for detecting neurotrophin 4/5 using immunohistochemistry, but we recommend ab6205 which is the affinity purified version of ab6204 and therefore likely to give less background.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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