Overview

  • Product nameAnti-Neurotrypsin antibody
    See all Neurotrypsin primary antibodies
  • Description
    Rabbit polyclonal to Neurotrypsin
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to 23 amino acids near the N-terminus of Human Neurotrypsin.

  • Positive control
    • Human Cortex and Human Lung tissues

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab118854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 97 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionPlays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
  • Tissue specificityBrain and Leydig cells of the testis.
  • Involvement in diseaseDefects in PRSS12 are the cause of mental retardation autosomal recessive type 1 (MRT1) [MIM:249500]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 1 kringle domain.
    Contains 1 peptidase S1 domain.
    Contains 4 SRCR domains.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BSSP 3 antibody
    • BSSP3 antibody
    • Leydin antibody
    • MGC12722 antibody
    • Motopsin antibody
    • MRT1 antibody
    • NETR_HUMAN antibody
    • Neurotrypsin antibody
    • protease, serine, 12 (neurotrypsin, motopsin) antibody
    • Prss12 antibody
    • Serine protease 12 antibody
    see all

Anti-Neurotrypsin antibody images

  • Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Human Cortex tissue using ab118854 at a concentration of 5 µg/ml.
  • Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Human Lung tissue using ab118854 at a concentration of 5 µg/ml.

References for Anti-Neurotrypsin antibody (ab118854)

ab118854 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"