The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. Predicted molecular weight: 97 kDa.
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
FunctionPlays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
Tissue specificityBrain and Leydig cells of the testis.
Involvement in diseaseDefects in PRSS12 are the cause of mental retardation autosomal recessive type 1 (MRT1) [MIM:249500]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
Sequence similaritiesBelongs to the peptidase S1 family. Contains 1 kringle domain. Contains 1 peptidase S1 domain. Contains 4 SRCR domains.