The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notes1 site ELISA: 1/5000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionSupports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
Involvement in diseaseDefects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
Sequence similaritiesBelongs to the TGF-beta family. GDNF subfamily.
Immunohistochemistry (Frozen sections) - Anti-Neurturin antibody (ab49203)Image from Liu W et al., Auris Nasus Larynx. 2013;S0385-8146(13):00188-0. Fig 5.; doi: 10.1016/j.anl.2013.07.016 with permission from Elsevier.
ab49203 staining Neurturin in Human cochleae tissue sections by Immunohistochemistry. Samples were incubated with primary antibody (1/100) for 20 hours at 4°C. Positive Neuturin immunostaining was found in the spiral ganglion cell bodies and nerve fibers. The circle indicates peripheral nerve processes, arrows point to the nerve bundles of the central processes.
References for Anti-Neurturin antibody (ab49203)
This product has been referenced in:
Liu W & Rask-Andersen H Immunohistological analysis of neurturin and its receptors in human cochlea. Auris Nasus LarynxN/A:N/A (2013).
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