Anti-Neurturin antibody [MM0486-5X51] (ab90450)

Overview

  • Product nameAnti-Neurturin antibody [MM0486-5X51]
    See all Neurturin primary antibodies
  • Description
    Mouse monoclonal [MM0486-5X51] to Neurturin
  • Tested applicationsSuitable for: WB, Neutralisingmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to the extracellular domain of Human Neurturin.

  • General notes


    Suitable for the neutralization of ligand/receptor interaction.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • Primary antibody notesSuitable for the neutralization of ligand/receptor interaction.
  • ClonalityMonoclonal
  • Clone numberMM0486-5X51
  • IsotypeIgG2
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab90450 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 22 kDa.
Neutralising Use at an assay dependent dilution.

Target

  • FunctionSupports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
  • Involvement in diseaseDefects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
  • Sequence similaritiesBelongs to the TGF-beta family. GDNF subfamily.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Neurturin antibody
    • Neurturin precursor antibody
    • NRTN antibody
    • NRTN_HUMAN antibody
    • NTN antibody
    • prepro-neurturin antibody
    see all

Anti-Neurturin antibody [MM0486-5X51] images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placental tissue section (4µm) labelling Neurturin with ab90450. Tissue was treated with 15µg/ml Protenase K for antigen retrieval and fixed with 4% PFA. A HRP-conjugated anti-mouse IgG was used as the secondary antibody (30 minutes at room temperature) followed by DAB color development.

References for Anti-Neurturin antibody [MM0486-5X51] (ab90450)

ab90450 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"