Anti-Neutrophil Elastase antibody [11-207.2] (ab41179)

Overview

  • Product name
    Anti-Neutrophil Elastase antibody [11-207.2]
    See all Neutrophil Elastase primary antibodies
  • Description
    Mouse monoclonal [11-207.2] to Neutrophil Elastase
  • Tested applications
    Suitable for: ELISA, Inhibition Assaymore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native protein (purified) (Human) Neutrophil Elastase

  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

Properties

Applications

Our Abpromise guarantee covers the use of ab41179 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/800.
Inhibition Assay Use at an assay dependent dilution.

Target

  • Function
    Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
  • Tissue specificity
    Bone marrow cells.
  • Involvement in disease
    Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.
    Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:202700]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
  • Sequence similarities
    Belongs to the peptidase S1 family. Elastase subfamily.
    Contains 1 peptidase S1 domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • Bone marrow serine protease antibody
    • ELA2 antibody
    • ELANE antibody
    • Elastase 2 antibody
    • Elastase 2 neutrophil antibody
    • Elastase neutrophil expressed antibody
    • Elastase-2 antibody
    • ELNE_HUMAN antibody
    • GE antibody
    • Granulocyte derived elastase antibody
    • HLE antibody
    • HNE antibody
    • Human leukocyte elastase antibody
    • Leukocyte elastase antibody
    • Medullasin antibody
    • NE antibody
    • Neutrophil elastase antibody
    • PMN E antibody
    • PMN elastase antibody
    • Polymorphonuclear elastase antibody
    • SCN1 antibody
    see all

References

This product has been referenced in:
  • Zoega M  et al. Proteinase 3 carries small unusual carbohydrates and associates with alpha-defensins. J Proteomics 75:1472-85 (2012). Read more (PubMed: 22138257) »

See 1 Publication for this product

Customer reviews and Q&As

Thank you for our reply and for kindly providing these details. I am sorry we regrettably do not have anything that exactly fits your requirements on this occasion. All the polyclonal antibodies to neutrophil elastase are not purified, they are...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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