Overview

  • Product nameNF 449
  • Description
    Highly selective, potent P2X1 receptor antagonist
  • Biological descriptionHighly selective, potent hP2X1 receptor antagonist (IC50 values are 0.05 nM (hP2X1), 40 μM (hP2X7), 0.28 (rP2X1), 0.69 (rP2X1/5), 120 (rP2X2/3), 1820 (rP2X3), 47000 (rP2X2) and >300000 nM (P2X4)). Suramin (ab120422) analog. Reduces collagen induced platelet aggregation and inhibits calcium influx.
  • Purity> 95%

Properties

  • Chemical name4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid octasodium salt
  • Molecular weight1505.06
  • Chemical structureChemical Structure
  • Molecular formulaC41H24N6Na8O29S8
  • CAS Number389142-38-5
  • PubChem identifier4469
  • Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in water to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESO=S(=O)(O[Na])c6ccc(NC(=O)c1cc(cc(c1)C(=O)Nc2ccc(cc2S(=O)(=O)O[Na])S(=O)(=O)O[Na])NC(=O)Nc3cc(cc(c3)C(=O)Nc4ccc(cc4S(=O)(=O)O[Na])S(=O)(=O)O[Na])C(=O)Nc5ccc(cc5S(=O)(=O)O[Na])S(=O)(=O)O[Na])c(c6)S(=O)(=O)O[Na]
  • Source

    Synthetic

  • Research areas

    References for NF 449 (ab120415)

    This product has been referenced in:
    • Rettinger J  et al. Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist. Neuropharmacology 48:461-8 (2005). Read more (PubMed: 15721178) »
    • Hechler B  et al. Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt]. J Pharmacol Exp Ther 314:232-43 (2005). Read more (PubMed: 15792995) »
    • Hülsmann M  et al. NF449, a novel picomolar potency antagonist at human P2X1 receptors. Eur J Pharmacol 470:1-7 (2003). Read more (PubMed: 12787824) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"