Overview

  • Product nameNF023
  • Description
    Competitive P2X1 receptor antagonist
  • Biological descriptionSuramin analog and subtype-selective competitive antagonist at P2X1 receptors (IC50 values are 0.21, 28.9, >50 and >100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses, respectively). Inhibits contraction induced by electrical field stimulation in smooth muscle.
  • Purity> 96%

Properties

  • Chemical name8,8'-[Carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
  • Molecular weight1162.86
  • Chemical structureChemical Structure
  • Molecular formulaC35H20N4Na6O21S6
  • CAS Number104869-31-0
  • PubChem identifier4465
  • Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESO=S(=O)(O[Na])c1cc(cc2c1c(ccc2S(=O)(=O)O[Na])NC(=O)c3cc(ccc3)NC(=O)Nc4cccc(c4)C(=O)Nc6ccc(c5cc(cc(c56)S(=O)(=O)O[Na])S(=O)(=O)O[Na])S(=O)(=O)O[Na])S(=O)(=O)O[Na]
  • Source

    Synthetic

  • Research areas

    References for NF023 (ab120454)

    This product has been referenced in:
    • Cho YR  et al. P2X and P2Y Receptors Mediate Contraction Induced by Electrical Field Stimulation in Feline Esophageal Smooth Muscle. Korean J Physiol Pharmacol 14:311-6 (2010). Read more (PubMed: 21165330) »
    • Soto F  et al. Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors. Neuropharmacology 38:141-9 (1999). Read more (PubMed: 10193905) »
    • Ralevic V & Burnstock G Receptors for purines and pyrimidines. Pharmacol Rev 50:413-92 (1998). Read more (PubMed: 9755289) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"