Synthetic peptide corresponding to Human NFAT4 (phospho S165) conjugated to Keyhole Limpet Haemocyanin (KLH). Peptide sequence around phosphorylation site of Serine 165 (S-P-S(p)-P-A) derived from Human NFAT4. NCBI Protein#: NP_004546.1. Database link: Q12968
HeLa cell extract.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.
Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.
Contains 1 RHD (Rel-like) domain.
Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.
Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.