May be a negative regulator of NF-kappa-B activation.
Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.
Involvement in disease
Defects in NFKBIL1 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Immunofluorescent analysis of MDA-MB435 cells labeling NFKBIL1 with ab170749 at 1/10 dilution followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue labeling NFKBIL1 with ab170749 at 1/10 dilution followed by peroxidase-conjugated secondary antibody and DAB staining.
Western blot - Anti-NFKBIL1 antibody - C-terminal (ab170749)
Anti-NFKBIL1 antibody - C-terminal (ab170749) at 1/100 dilution + MDA-MB435 cell lysate at 35 µg