Overview

  • Product nameAnti-NFKBIL2 antibody
    See all NFKBIL2 primary antibodies
  • Description
    Rabbit polyclonal to NFKBIL2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 325-374 (GGRRGGALRE RGRHRWPDPA AGGGRGASGP PGAAKGSKWN RRNDMGETLL) of Human NFKBIL2 (NP_038460)

  • Positive control
    • 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab83778 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 151 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionComponent of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.
  • Tissue specificityExpressed in heart, skeletal muscle and tracheal epithelial cells.
  • Sequence similaritiesBelongs to the Tonsoku family.
    Contains 3 ANK repeats.
    Contains 7 LRR (leucine-rich) repeats.
    Contains 8 TPR repeats.
  • DomainThe ANK repeats mediate the interaction with the MCM complex and histones, while the LRR repeats mediate the interaction with MMS22L.
  • Cellular localizationCytoplasm. Nucleus. Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
  • Information by UniProt
  • Database links
  • Alternative names
    • I kappa B related protein antibody
    • I-kappa-B-related protein antibody
    • IkappaBR antibody
    • IKBR antibody
    • Inhibitor of kappa B related protein antibody
    • Inhibitor of kappa B-related protein antibody
    • MMS22L-interacting protein antibody
    • MMS22L-interacting protein, NFBIL2/TONSL antibody
    • NF kappa B inhibitor like protein 2 antibody
    • NF-kappa-B inhibitor-like protein 2 antibody
    • NFBIL2 antibody
    • NFBIL2/TONSL antibody
    • Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like protein 2 antibody
    • Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 antibody
    • Protein IkappaBR antibody
    • Tonsl antibody
    • TONSL_HUMAN antibody
    • Tonsoku-like protein antibody
    • tonsoku-like, DNA repair protein antibody
    see all

Anti-NFKBIL2 antibody images

  • Anti-NFKBIL2 antibody (ab83778) at 1 µg/ml + 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 151 kDa
    Observed band size : 155 kDa (why is the actual band size different from the predicted?)

References for Anti-NFKBIL2 antibody (ab83778)

ab83778 has not yet been referenced specifically in any publications.

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