Overview

  • Product nameAnti-NGF antibody
    See all NGF primary antibodies
  • Description
    Rabbit polyclonal to NGF
  • Tested applicationsSuitable for: Dot blot, Inhibition Assay, WBmore details
  • Species reactivity
    Reacts with: Mouse, Chicken, Human
  • Immunogen

    NGF from male mouse submaxillary glands.

Properties

Applications

Our Abpromise guarantee covers the use of ab10515 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot
Inhibition Assay
WB
  • Application notesDot: 1/2000 to detect 3 ng or less of NGF in a dot blot immunoassay.
    Inhib: A minimum antibody dilution of 1/10000 blocks the ability of NGF to stimulate growth of PC-12 cells or chick dorsal root ganglia.
    WB: A minimum antibody dilution of 1/2000 will detect 500 ng of NGF in a western blot, but will not react significantly with contaminants present in a mouse submaxillary gland extract.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
    • Involvement in diseaseNeuropathy, hereditary sensory and autonomic, 5
    • Sequence similaritiesBelongs to the NGF-beta family.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • Beta nerve growth factor antibody
      • Beta NGF antibody
      • Beta-nerve growth factor antibody
      • Beta-NGF antibody
      • HSAN5 antibody
      • MGC161426 antibody
      • MGC161428 antibody
      • Nerve growth factor (beta polypeptide) antibody
      • Nerve growth factor antibody
      • Nerve growth factor beta antibody
      • Nerve growth factor beta polypeptide antibody
      • Nerve growth factor beta subunit antibody
      • NGF antibody
      • NGF_HUMAN antibody
      • NGFB antibody
      • NID67 antibody
      see all

    References for Anti-NGF antibody (ab10515)

    This product has been referenced in:
    • Kirkland RA  et al. Rapid activation of antioxidant defenses by nerve growth factor suppresses reactive oxygen species during neuronal apoptosis: evidence for a role in cytochrome c redistribution. J Neurosci 27:11315-26 (2007). Read more (PubMed: 17942726) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"