Overview

  • Product name
  • Description
    Goat polyclonal to NGF
  • Tested applications
    Suitable for: ELISA, WB, Neutralisingmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Recombinant full length rat NGF beta protein expressed in Sf 21 insect cells.

  • Positive control
    • Tested with human erythroleukemic cells (TF-1) expressing recombinant rat NGF beta.

Properties

Applications

Our Abpromise guarantee covers the use of ab10837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 0.5 - 1 µg/ml.
WB Use a concentration of 0.1 - 0.2 µg/ml. Detects a band of approximately 13.2 kDa.
Neutralising Use a concentration of 0.05 - 0.15 µg/ml.

Target

  • Function
    Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
  • Involvement in disease
    Neuropathy, hereditary sensory and autonomic, 5
  • Sequence similarities
    Belongs to the NGF-beta family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beta nerve growth factor antibody
    • Beta NGF antibody
    • Beta-nerve growth factor antibody
    • Beta-NGF antibody
    • HSAN5 antibody
    • MGC161426 antibody
    • MGC161428 antibody
    • Nerve growth factor (beta polypeptide) antibody
    • Nerve growth factor antibody
    • Nerve growth factor beta antibody
    • Nerve growth factor beta polypeptide antibody
    • Nerve growth factor beta subunit antibody
    • NGF antibody
    • NGF_HUMAN antibody
    • NGFB antibody
    • NID67 antibody
    see all

References

This product has been referenced in:
  • Huang M  et al. Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells. Oncotarget 7:74917-74930 (2016). Read more (PubMed: 27732946) »

See 1 Publication for this product

Customer reviews and Q&As

Thank you for providing some more useful information about your experimental system. I understand now from your recent e-mail, that you used Cos-7 cells (monkey) transfected with a vector carrying the coding part of the human NGFb gene. I have disc...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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