Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human NHP2 aa 100 to the C-terminus (Cysteine residue). The exact sequence is proprietary. Database link: Q9NX24
K562, Jurkat, Caco 2 and SH-SY5Y cell lysate; Human pancreas and spleen tissues; Caco 2 and K562 cells.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver.
Involvement in disease
Dyskeratosis congenita, autosomal recessive, 2
Belongs to the ribosomal protein L7Ae family.
Transcript peaks at G1/S transition.
Nucleus > nucleolus. Nucleus > Cajal body. Also localized to Cajal bodies.