Anti-Nicastrin antibody [EPR2574] (ab108993)

Overview

  • Product nameAnti-Nicastrin antibody [EPR2574]
    See all Nicastrin primary antibodies
  • Description
    Rabbit monoclonal [EPR2574] to Nicastrin
  • Tested applicationsSuitable for: WB, ICCmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to residues in Human Nicastrin.

  • Positive control
    • A431, Jurkat, HeLa and 293T cell lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

Applications

Our Abpromise guarantee covers the use of ab108993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 78 kDa.
ICC 1/100 - 1/250.
  • Application notesIs unsuitable for Flow Cyt,IHC-P or IP.
  • Target

    • FunctionEssential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
    • Tissue specificityWidely expressed.
    • Sequence similaritiesBelongs to the nicastrin family.
    • Cellular localizationMembrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    • Information by UniProt
    • Database links
    • Alternative names
      • Anterior pharynx defective 2 antibody
      • APH 2 antibody
      • APH2 antibody
      • ATAG1874 antibody
      • KIAA0253 antibody
      • Ncstn antibody
      • NCT antibody
      • NICA_HUMAN antibody
      • Nicastrin antibody
      • RP11 517F10.1 antibody
      • RP11517F101 antibody
      see all

    Anti-Nicastrin antibody [EPR2574] images

    • All lanes : Anti-Nicastrin antibody [EPR2574] (ab108993) at 1/1000 dilution

      Lane 1 : A431 cell lysate
      Lane 2 : Jurkat cell lysate
      Lane 3 : HeLa cell lysate
      Lane 4 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 78 kDa

    References for Anti-Nicastrin antibody [EPR2574] (ab108993)

    ab108993 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab108993.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"