Overview

  • Product name
    Niclosamide
  • Description
    Antihelminthic, anticancer and protonophric agent. STAT3 inhibitor.
  • Biological description
    Antihelminthic, anticancer and protonophric agent. STAT3 inhibitor (IC50 = 0.25 μM). Shown to inhibit a number of downstream signaling pathways including mTORC1, Wnt/β-catinin, NF-κB, notch and ROS.
  • Purity
    > 95%

Properties

References

This product has been referenced in:
  • Pan JX  et al. Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells. Chin J Cancer 31:178-84 (2012). Read more (PubMed: 22237038) »
  • Fonseca BD  et al. Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem 287:17530-45 (2012). Read more (PubMed: 22474287) »
  • Lu W  et al. Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/ß-catenin pathway. PLoS One 6:e29290 (2011). Read more (PubMed: 22195040) »
  • Jin Y  et al. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res 70:2516-27 (2010). Read more (PubMed: 20215516) »

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