Overview

  • Product name
    Nicotinamide
  • Description
    Amide form of vitamin B3
  • Biological description
    Amide form of vitamin B3. Plasma membrane and blood-brain barrier permeable. Precursor for β-nicotinamide adenine dinucleotide (NAD+). Essential for the synthesis of NAD+ phosphate (NADP+). Essential for energy metabolism, normal physiology and disease progression. Associated with a number of signaling pathways including oxidative stress, cell survival and inflammation. These effects are orchestrated partly through forkhead, Akt, Bad, caspase, MAPK and PARP signaling. Non-selective sirtuin inhibitor.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Wang H  et al. Different effects of histone deacetylase inhibitors nicotinamide and trichostatin A (TSA) in C17.2 neural stem cells. J Neural Transm : (2012). Read more (PubMed: 22407380) »
  • Maiese K  et al. The vitamin nicotinamide: translating nutrition into clinical care. Molecules 14:3446-85 (2009). Read more (PubMed: 19783937) »
  • Kaneko S  et al. Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models. J Neurosci 26:9794-804 (2006). Read more (PubMed: 16988050) »
  • Avalos JL  et al. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell 17:855-68 (2005). Read more (PubMed: 15780941) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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