Anti-Nicotinic Acetylcholine Receptor alpha 3 antibody (ab103956)

Overview

  • Product name
    Anti-Nicotinic Acetylcholine Receptor alpha 3 antibody
    See all Nicotinic Acetylcholine Receptor alpha 3 primary antibodies
  • Description
    Rabbit polyclonal to Nicotinic Acetylcholine Receptor alpha 3
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 30-60 of Human Nicotinic Acetylcholine Receptor alpha 3, conjugated to KLH.

  • Positive control
    • CEM cell line lysate; Human brain tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    This antibody is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab103956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 57 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • Sequence similarities
    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily.
  • Cellular localization
    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACHA3_HUMAN antibody
    • AChR antibody
    • Cholinergic receptor neuronal nicotinic alpha polypeptide 3 antibody
    • Cholinergic receptor nicotinic alpha 3 antibody
    • Cholinergic receptor nicotinic alpha polypeptide 3 antibody
    • CHRNA 3 antibody
    • CHRNA3 antibody
    • LNCR2 antibody
    • MGC104879 antibody
    • NACHRA 3 antibody
    • NACHRA3 antibody
    • Neuronal acetylcholine receptor protein alpha 3 chain precursor antibody
    • Neuronal acetylcholine receptor subunit alpha 3 antibody
    • Neuronal acetylcholine receptor subunit alpha-3 antibody
    • Neuronal nicotinic acetylcholine receptor alpha 3 subunit antibody
    • PAOD2 antibody
    see all

Anti-Nicotinic Acetylcholine Receptor alpha 3 antibody images

  • Anti-Nicotinic Acetylcholine Receptor alpha 3 antibody (ab103956) at 1/100 dilution + CEM cell line lysate at 35 µg

    Predicted band size : 57 kDa
  • ab103956, at a 1/50 dilution, staining Nicotinic Acetylcholine Receptor alpha 3 in formalin fixed and paraffin embedded Human brain tissue by Immunochemistry. Developed using peroxidase conjugated secondary antibody and DAB staining.

References for Anti-Nicotinic Acetylcholine Receptor alpha 3 antibody (ab103956)

This product has been referenced in:
  • He P  et al. CHRNA3 polymorphism modifies lung adenocarcinoma risk in the Chinese Han population. Int J Mol Sci 15:5446-57 (2014). IHC-P ; Human . Read more (PubMed: 24686516) »
  • Al-Wadei MH  et al. Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia. Cancer Prev Res (Phila) 6:139-48 (2013). WB ; Human . Read more (PubMed: 23213073) »

See all 4 Publications for this product

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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