Anti-Nicotinic Acetylcholine Receptor alpha 5 antibody (ab41173)

Overview

  • Product nameAnti-Nicotinic Acetylcholine Receptor alpha 5 antibody
    See all Nicotinic Acetylcholine Receptor alpha 5 primary antibodies
  • Description
    Rabbit polyclonal to Nicotinic Acetylcholine Receptor alpha 5
  • SpecificityAntiserum Specificity Polypeptide % Cross Reactivity Nicotinic a5 receptor (460-468) 100%, Nicotinic a5 receptor ~95%, Nicotinic a3 receptor 0%, Nicotinic a4 receptor 0%, Nicotinic a7 receptor 0%, Nicotinic ß2 receptor 0%, Nicotinic ß3 receptor 0%, Nicotinic ß4 receptor 0%.
  • Tested applicationsSuitable for: ICC/IF, ELISA, WBmore details
  • Species reactivity
    Reacts with: Human, Chimpanzee, Monkey
  • Immunogen

    Synthetic peptide:

    PVHIGNANK

    , corresponding to C terminal amino acids 460-468 of Nicotinic Acetylcholine Receptor alpha 5

Properties

Applications

Our Abpromise guarantee covers the use of ab41173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
ELISA
WB
  • Application notesELISA: Use at an assay dependent dilution.
    ICC/IF: 1/400.
    WB: 1/1600. Predicted molecular weight: 53 kDa.

    With this antibody, we have found that blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAfter binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    • Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
    • Cellular localizationCell junction > synapse > postsynaptic cell membrane. Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Acetylcholine receptor nicotinic alpha 5 (neuronal) antibody
      • ACHA5_HUMAN antibody
      • AChR antibody
      • Cholinergic receptor neuronal nicotinic alpha polypeptide 5 antibody
      • Cholinergic receptor nicotinic alpha 5 antibody
      • Cholinergic receptor nicotinic alpha polypeptide 5 antibody
      • CHRNA 5 antibody
      • CHRNA5 antibody
      • LNCR2 antibody
      • NACHRA 5 antibody
      • NACHRA5 antibody
      • Neuronal acetylcholine receptor subunit alpha 5 antibody
      • Neuronal acetylcholine receptor subunit alpha-5 antibody
      • Neuronal nicotinic acetylcholine receptor alpha 5 subunit antibody
      • Neuronal nicotinic acetylcholine receptor, alpha5 subunit antibody
      • OTTHUMP00000185019 antibody
      see all

    References for Anti-Nicotinic Acetylcholine Receptor alpha 5 antibody (ab41173)

    This product has been referenced in:
    • Calleja-Macias IE  et al. Cholinergic signaling through nicotinic acetylcholine receptors stimulates the proliferation of cervical cancer cells: an explanation for the molecular role of tobacco smoking in cervical carcinogenesis? Int J Cancer 124:1090-6 (2009). WB ; Human . Read more (PubMed: 19048619) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"