Anti-Nicotinic Acetylcholine Receptor beta 2 antibody (ab85693)

Overview

  • Product name
    Anti-Nicotinic Acetylcholine Receptor beta 2 antibody
    See all Nicotinic Acetylcholine Receptor beta 2 primary antibodies
  • Description
    Goat polyclonal to Nicotinic Acetylcholine Receptor beta 2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rhesus monkey
  • Immunogen

    Synthetic peptide:

    QPRHHCARQRLR

    , corresponding to internal sequence amino acids 351-362 of Human Nicotinic Acetylcholine Receptor beta 2 (NP_000739.1).

  • Positive control
    • Human Brain (Cerebellum, Cerebral Cortex) lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab85693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 48 kDa (predicted molecular weight: 57 kDa).

Target

  • Function
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • Involvement in disease
    Defects in CHRNB2 are the cause of nocturnal frontal lobe epilepsy type 3 (ENFL3) [MIM:605375]. ENFL3 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.
  • Sequence similarities
    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.
  • Cellular localization
    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Acetylcholine receptor beta 2 neural antibody
    • ACHB2_HUMAN antibody
    • ACHN antibody
    • AChR antibody
    • Acrb 2 antibody
    • Acrb2 antibody
    • b2 nAchR antibody
    • Cholinergic receptor nicotinic beta 2 antibody
    • Cholinergic receptor nicotinic beta polypeptide 2 antibody
    • Cholinergic receptor nicotinic beta polypeptide 2 neuronal antibody
    • cholinergic receptor, nicotinic, beta 2 (neuronal) antibody
    • Chrnb2 antibody
    • EFNL 3 antibody
    • EFNL3 antibody
    • nAChRB2 antibody
    • Neuronal acetylcholine receptor protein beta 2 chain precursor antibody
    • Neuronal acetylcholine receptor protein subunit beta 2 antibody
    • Neuronal acetylcholine receptor subunit beta-2 antibody
    • Neuronal nicotinic acetylcholine receptor beta 2 antibody
    see all

Images

  • Anti-Nicotinic Acetylcholine Receptor beta 2 antibody (ab85693) at 1 µg/ml + Human cerebellum lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 57 kDa
    Observed band size : 48 kDa (why is the actual band size different from the predicted?)

References

ab85693 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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