Anti-Nicotinic Acetylcholine Receptor beta 4 antibody - C-terminal (ab156213)

Overview

  • Product name
    Anti-Nicotinic Acetylcholine Receptor beta 4 antibody - C-terminal
    See all Nicotinic Acetylcholine Receptor beta 4 primary antibodies
  • Description
    Rabbit polyclonal to Nicotinic Acetylcholine Receptor beta 4 - C-terminal
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 422-450 of Human Nicotinic Acetylcholine Receptor beta 4 (NP_000741.1)

  • Positive control
    • 293 cell lysates

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store undiluted.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99.91% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab156213 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab156213 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 56 kDa.

Target

  • Function
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • Sequence similarities
    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily.
  • Cellular localization
    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • acetylcholine receptor, nicotinic, beta 4 (neuronal) antibody
    • ACHB4_HUMAN antibody
    • AChR antibody
    • Cholinergic receptor nicotinic beta 4 antibody
    • Cholinergic receptor nicotinic beta polypeptide 4 antibody
    • cholinergic receptor, nicotinic, beta polypeptide 4 antibody
    • Chrnb4 antibody
    • Neuronal acetylcholine receptor subunit beta-4 antibody
    • Neuronal nicotinic receptor beta 4 subunit antibody
    see all

Images

  • Anti-Nicotinic Acetylcholine Receptor beta 4 antibody - C-terminal (ab156213) at 1/100 dilution + 293 cell lysate at 35 µg

    Predicted band size : 56 kDa

References

This product has been referenced in:
  • Lyukmanova EN  et al. Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors. Sci Rep 6:30698 (2016). WB . Read more (PubMed: 27485575) »
  • Lyukmanova EN  et al. Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of a7 Nicotinic Acetylcholine Receptor. PLoS One 11:e0149733 (2016). WB . Read more (PubMed: 26905431) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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