Anti-Nicotinic Acetylcholine Receptor epsilon antibody (ab65180)

Overview

  • Product nameAnti-Nicotinic Acetylcholine Receptor epsilon antibody
    See all Nicotinic Acetylcholine Receptor epsilon primary antibodies
  • Description
    Rabbit polyclonal to Nicotinic Acetylcholine Receptor epsilon
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, a wide range of other species
  • Immunogen

    Synthetic peptide derived from C terminal human Nicotinic Acetylcholine Receptor epsilon.

Properties

Applications

Our Abpromise guarantee covers the use of ab65180 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 55 kDa.

Target

  • FunctionAfter binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • Involvement in diseaseThe muscle AChR is the major target antigen in the autoimmune disease myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
    Myasthenic syndrome, congenital, 4A, slow-channel
    Myasthenic syndrome, congenital, 4B, fast-channel
    Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency
  • Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.
  • Cellular localizationCell junction, synapse, postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Acetylcholine receptor subunit epsilon antibody
    • ACHE_HUMAN antibody
    • AChR antibody
    • AchR epsilon subunit antibody
    • ACHRE antibody
    • Cholinergic receptor, nicotinic, epsilon polypeptide antibody
    • Chrne antibody
    • CMS1D antibody
    • CMS1E antibody
    • CMS2A antibody
    • FCCMS antibody
    • SCCMS antibody
    see all

References for Anti-Nicotinic Acetylcholine Receptor epsilon antibody (ab65180)

ab65180 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 25 µg
Gel Running Conditions Non-reduced Denaturing (10% gel BioRad, Running Buffer BioRad.)
Sample Mouse Tissue lysate - whole (tibialis muscle)
Specification tibialis muscle
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 26°C
Username

Ms. Lisa Marienhoff

Verified customer

Submitted Dec 03 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"