Anti-Nicotinic Acetylcholine Receptor gamma antibody [66] (ab24667)


  • Product nameAnti-Nicotinic Acetylcholine Receptor gamma antibody [66]
    See all Nicotinic Acetylcholine Receptor gamma primary antibodies
  • Description
    Rat monoclonal [66] to Nicotinic Acetylcholine Receptor gamma
  • Specificityab24667 recognises Nicotinic Acetylcholine Receptor gamma .
  • Tested applicationsSuitable for: WB, IP, ICC/IFmore details
  • Species reactivity
    Reacts with: Cow, Human
    Does not react with: Rat
  • Immunogen

    Full length native protein (purified) (Cow): purified bovine muscle nicotinic acetylcholine receptor.

  • General notes

    ab24667 is useful to study specificities of autoantibodies in myasthenia gravis (MG) patient sera.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: Ascites
  • Concentration information loading...
  • PurityAscites
  • Primary antibody notesab24667 is useful to study specificities of autoantibodies in myasthenia gravis (MG) patient sera.
  • ClonalityMonoclonal
  • Clone number66
  • IsotypeIgG2a
  • Research areas


Our Abpromise guarantee covers the use of ab24667 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 58 kDa.
IP 1/100.
ICC/IF 1/250 - 1/500.


  • FunctionAfter binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • Involvement in diseaseDefects in CHRNG are a cause of multiple pterygium syndrome lethal type (MUPSL) [MIM:253290]. Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent.
    Defects in CHRNG are a cause of multiple pterygium syndrome Escobar variant (MUPSE) [MIM:265000]; also known as nonlethal type multiple pterygium syndrome. Escobar syndrome is a non-lethal form of arthrogryposis multiplex congenita. It is an autosomal recessive condition characterized by excessive webbing (pterygia), congenital contractures (arthrogryposis), and scoliosis. Variable other features include intrauterine death, congenital respiratory distress, short stature, faciocranial dysmorphism, ptosis, low-set ears, arachnodactyly and cryptorchism in males. Congenital contractures are common and may be caused by reduced fetal movements at sensitive times of development. Possible causes of decreased fetal mobility include space constraints such as oligohydramnion, drugs, metabolic conditions or neuromuscular disorders including myasthenia gravis. is a.
  • Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily.
  • Cellular localizationCell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Acetylcholine receptor muscle gamma subunit antibody
    • Acetylcholine receptor protein gamma chain precursor antibody
    • Acetylcholine receptor subunit gamma antibody
    • ACHG antibody
    • ACHG_HUMAN antibody
    • Achr 3 antibody
    • AChR antibody
    • Achr3 antibody
    • ACHRG antibody
    • ACRG antibody
    • Cholinergic receptor nicotinic gamma antibody
    • Cholinergic receptor nicotinic gamma polypeptide antibody
    • CHRNG antibody
    • MGC133376 antibody
    see all

References for Anti-Nicotinic Acetylcholine Receptor gamma antibody [66] (ab24667)

ab24667 has not yet been referenced specifically in any publications.

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