Overview

  • Product nameAnti-Niemann Pick C2 antibody
    See all Niemann Pick C2 primary antibodies
  • Description
    Goat polyclonal to Niemann Pick C2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide:

    QAEPLHFKDCGSK

    , corresponding to internal sequence amino acids 18-30 of Mouse Niemann Pick C2 (NP_075898).

  • Positive control
    • Mouse kidney lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab114047 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 16 kDa (predicted molecular weight: 16 kDa).

Target

  • FunctionMay be involved in the regulation of the lipid composition of sperm membranes during the maturation in the epididymis.
  • Tissue specificityEpididymis.
  • Involvement in diseaseDefects in NPC2 are the cause of Niemann-Pick disease type C2 (NPDC2) [MIM:607625]. A lysosomal storage disorder that affects the viscera and the central nervous system. It is due to defective intracellular processing and transport of low-density lipoprotein derived cholesterol. It causes accumulation of cholesterol in lysosomes, with delayed induction of cholesterol homeostatic reactions. Niemann-Pick disease type C2 has a highly variable clinical phenotype. Clinical features include variable hepatosplenomegaly and severe progressive neurological dysfunction such as ataxia, dystonia and dementia. The age of onset can vary from infancy to late adulthood.
  • Sequence similaritiesBelongs to the NPC2 family.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • EDDM1 antibody
    • Epididymal protein 1 antibody
    • Epididymal secretory protein antibody
    • Epididymal secretory protein E1 antibody
    • hE1 antibody
    • Human epididymis-specific protein 1 antibody
    • Niemann-Pick disease type C2 antibody
    • Niemann-Pick disease type C2 protein antibody
    • NPC intracellular cholesterol transporter 2 antibody
    • NPC2 antibody
    • NPC2_HUMAN antibody
    • Tissue specific secretory protein antibody
    see all

Anti-Niemann Pick C2 antibody images

  • Anti-Niemann Pick C2 antibody (ab114047) at 0.1 µg/ml + Mouse kidney lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 16 kDa


    Exposure time : 1 hour

References for Anti-Niemann Pick C2 antibody (ab114047)

ab114047 has not yet been referenced specifically in any publications.

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