Overview

  • Product name
    Anti-Niemann Pick C2 antibody
    See all Niemann Pick C2 primary antibodies
  • Description
    Rabbit polyclonal to Niemann Pick C2
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-101 of Human Niemann Pick C2 (P61916).

  • Positive control
    • HeLa whole cell lysate; Human U87 xenograft tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab126190 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 17 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    May be involved in the regulation of the lipid composition of sperm membranes during the maturation in the epididymis.
  • Tissue specificity
    Epididymis.
  • Involvement in disease
    Defects in NPC2 are the cause of Niemann-Pick disease type C2 (NPDC2) [MIM:607625]. A lysosomal storage disorder that affects the viscera and the central nervous system. It is due to defective intracellular processing and transport of low-density lipoprotein derived cholesterol. It causes accumulation of cholesterol in lysosomes, with delayed induction of cholesterol homeostatic reactions. Niemann-Pick disease type C2 has a highly variable clinical phenotype. Clinical features include variable hepatosplenomegaly and severe progressive neurological dysfunction such as ataxia, dystonia and dementia. The age of onset can vary from infancy to late adulthood.
  • Sequence similarities
    Belongs to the NPC2 family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • EDDM1 antibody
    • Epididymal protein 1 antibody
    • Epididymal secretory protein antibody
    • Epididymal secretory protein E1 antibody
    • hE1 antibody
    • Human epididymis-specific protein 1 antibody
    • Niemann-Pick disease type C2 antibody
    • Niemann-Pick disease type C2 protein antibody
    • NPC intracellular cholesterol transporter 2 antibody
    • NPC2 antibody
    • NPC2_HUMAN antibody
    • Tissue specific secretory protein antibody
    see all

Images

  • Anti-Niemann Pick C2 antibody (ab126190) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 17 kDa
  • ab126190, at 1/500 dilution, staining Niemann Pick C2 in Paraffin-embedded Human U87 xenograft tissue by Immunohistochemistry.

References

ab126190 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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