Nimodipine (ab120138)

Overview

• Product name
  Nimodipine
• Description
  L-type Ca²⁺ channel blocker
• Biological description
  L-type Ca²⁺ channel blocker. Potent cerebrovasodilator. Cognitive enhancer. More lipophilic than nifedipine (ab120135).
• Purity
  > 98%
• General notes

  Nimodipine is light sensitive and it is recommended that the compound is protected from light.

Properties

• Chemical name
  1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester
• Molecular weight
  418.44
• Chemical structure
  
• Molecular formula
  C₂₁H₂₆N₂O₇
• CAS Number
  66085-59-4
• PubChem identifier
  4497
• Storage instructions
  Store at Room Temperature. The product can be stored for up to 12 months.
• Solubility overview
  Soluble in DMSO to 100 mM and in ethanol to 10 mM
• Handling

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES
  CC=1NC(C)=C(C(C=1C(=O)OC(C)C)c2cccc(c2)[N+]([O-])=O)C(=O)OCCOC
• Source

  Synthetic

• Research areas
  • Biochemicals
  • Chemical Type
  • Biochemicals

  • Biochemicals
  • Pharmacology
  • Ion Channels
  • Calcium
  • Blockers

  • Biochemicals
  • Pharmacology
  • Signaling
  • Ca²⁺ signaling
  • Ca_v channels

  • Biochemicals
  • Research Area
  • Heart disease
  • Calcium

  • Biochemicals
  • Research Area
  • Heart disease
  • Signaling
  • Ca²⁺ signaling
  • Ca_v channels

  • Biochemicals
  • Research Area
  • Pain & inflammation
  • Signaling
  • Ca²⁺ signaling
  • Ca_v channels

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  • Alzheimer's Disease
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  • Ca²⁺ signaling
  • Ca_v channels

  • Biochemicals
  • Research Area
  • Diabetes
  • Ca²⁺ signaling
  • Ca_v channels

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  • Diabetes
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  • Ca²⁺ signaling
  • Ca_v channels

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  • Heart disease
  • Ca²⁺ signaling
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  • Hypertension
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  • Hypertension
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  • Ca²⁺ signaling
  • Ca_v channels

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  • Obesity
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  • Obesity
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  • Stroke
  • Signaling
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  • Ca_v channels

  • Biochemicals
  • Research Area
  • Cancer
  • Ca²⁺ signaling
  • Ca_v channels

Nimodipine images

• 

  Functional Studies - Nimodipine (ab120138)
  ab2770 staining aryl hydrocarbon receptor in MDA-MB-231 cells treated with nimodipine (ab120138), by ICC/IF. Increase in aryl hydrocarbon receptor expression correlates with increased concentration of nimodipine, as described in literature.
  The cells were incubated at 37°C for 6h in media containing different concentrations of ab120138 (nimodipine) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2770 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.