- Datasheet
- Specific References (2)
Overview
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Product nameNimodipine
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DescriptionL-type Ca2+ channel blocker
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Biological descriptionL-type Ca2+ channel blocker. Potent cerebrovasodilator. Cognitive enhancer. More lipophilic than nifedipine (ab120135).
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Purity> 98%
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General notes
Nimodipine is light sensitive and it is recommended that the compound is protected from light.
Properties
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Chemical name1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester
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Molecular weight418.44
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Chemical structure
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Molecular formulaC21H26N2O7
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CAS Number66085-59-4
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PubChem identifier4497
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Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
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Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 10 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILESCC=1NC(C)=C(C(C=1C(=O)OC(C)C)c2cccc(c2)[N+]([O-])=O)C(=O)OCCOC
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Source
Synthetic
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Research areas
Applications
Our Abpromise guarantee covers the use of ab120138 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Functional Studies | Use at an assay dependent concentration. |
Images
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Functional Studies - Nimodipine (ab120138)ab2770 staining aryl hydrocarbon receptor in MDA-MB-231 cells treated with nimodipine (ab120138), by ICC/IF. Increase in aryl hydrocarbon receptor expression correlates with increased concentration of nimodipine, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120138 (nimodipine) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2770 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
References
This product has been referenced in:
- Fanelli RJ et al. Neuropharmacology of nimodipine: from single channels to behavior. Ann N Y Acad Sci 747:336-50 (1994). Read more (PubMed: 7847682) »
- de Jonge MC & Traber J Nimodipine: cognition, aging, and degeneration. Clin Neuropharmacol 16 Suppl 1:S25-30 (1993). Read more (PubMed: 8518999) »
- Scriabine A & van den Kerckhoff W Pharmacology of nimodipine. A review. Ann N Y Acad Sci 522:698-706 (1988). Read more (PubMed: 3288065) »
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"