The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
FunctionCatalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions.
Tissue specificityDetected in brain and spleen, and at low levels in ovary.
Involvement in diseaseDefects in PITPNM3 are the cause of cone-rod dystrophy type 5 (CORD5) [MIM:600977]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.
Sequence similaritiesBelongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. Contains 1 DDHD domain.
ab115593, at 5 µg/ml, staining NIR1 in formalin fixed, paraffin embedded Human brain, cortex by Immunohistochemistry. After incubation with the primary antibody, slides were incubated with biotinylated anti-goat secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
References for Anti-NIR1 antibody (ab115593)
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