Overview

  • Product nameAnti-NIR1 antibody
    See all NIR1 primary antibodies
  • Description
    Goat polyclonal to NIR1
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide:

    SWARGPPKFESVP

    , corresponding to C terminal amino acids 962-974 of Human NIR1 (UniProt ID: Q9BZ71).

  • Positive control
    • Human brain cortex

Properties

Applications

Our Abpromise guarantee covers the use of ab115593 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/16000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionCatalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions.
  • Tissue specificityDetected in brain and spleen, and at low levels in ovary.
  • Involvement in diseaseDefects in PITPNM3 are the cause of cone-rod dystrophy type 5 (CORD5) [MIM:600977]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.
  • Sequence similaritiesBelongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
    Contains 1 DDHD domain.
  • Cellular localizationEndomembrane system.
  • Information by UniProt
  • Database links
  • Alternative names
    • CORD5 antibody
    • Membrane associated phosphatidylinositol transfer protein 3 antibody
    • membrane-associated 3 antibody
    • Membrane-associated phosphatidylinositol transfer protein 3 antibody
    • MGC157740 antibody
    • MGC157741 antibody
    • NIR 1 antibody
    • NIR-1 antibody
    • NIR1 antibody
    • Phosphatidylinositol transfer protein antibody
    • Phosphatidylinositol transfer protein, membrane-associated 3 antibody
    • PITM3_HUMAN antibody
    • PITPnm 3 antibody
    • PITPNM antibody
    • PITPNM family member 3 antibody
    • Pitpnm3 antibody
    • PYK2 N terminal domain interacting receptor 1 antibody
    • Pyk2 N-terminal domain-interacting receptor 1 antibody
    • RDGBA3 antibody
    • Retinal degeneration B alpha 3 antibody
    see all

Anti-NIR1 antibody images

  • ab115593, at 5 µg/ml, staining NIR1 in formalin fixed, paraffin embedded Human brain, cortex by Immunohistochemistry. After incubation with the primary antibody, slides were incubated with biotinylated anti-goat secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

References for Anti-NIR1 antibody (ab115593)

ab115593 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"