Overview

  • Product name
  • Description
    Goat polyclonal to NIR1
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide:

    SWARGPPKFESVP

    , corresponding to C terminal amino acids 962-974 of NIR1.

  • Positive control
    • Human Heart lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab21197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
WB
  • Application notes
    IHC-P: Use at a concentration of 5 µg/ml.
    Peptide ELISA: antibody detection limit dilution 1:16,000.
    Western Blot: Preliminary experiments gave an approx 50kDa band in Human Heart lysates after 0.1µg/ml antibody staining. The 50kDa band was successfully blocked by incubation with the immunizing peptide.
    Please note that currently we cannot find an explanation in the literature for the band we observed at size of 107kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions.
    • Tissue specificity
      Detected in brain and spleen, and at low levels in ovary.
    • Involvement in disease
      Defects in PITPNM3 are the cause of cone-rod dystrophy type 5 (CORD5) [MIM:600977]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.
    • Sequence similarities
      Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
      Contains 1 DDHD domain.
    • Cellular localization
      Endomembrane system.
    • Information by UniProt
    • Database links
    • Alternative names
      • CORD5 antibody
      • Membrane associated phosphatidylinositol transfer protein 3 antibody
      • membrane-associated 3 antibody
      • Membrane-associated phosphatidylinositol transfer protein 3 antibody
      • MGC157740 antibody
      • MGC157741 antibody
      • NIR 1 antibody
      • NIR-1 antibody
      • NIR1 antibody
      • Phosphatidylinositol transfer protein antibody
      • Phosphatidylinositol transfer protein, membrane-associated 3 antibody
      • PITM3_HUMAN antibody
      • PITPnm 3 antibody
      • PITPNM antibody
      • PITPNM family member 3 antibody
      • Pitpnm3 antibody
      • PYK2 N terminal domain interacting receptor 1 antibody
      • Pyk2 N-terminal domain-interacting receptor 1 antibody
      • RDGBA3 antibody
      • Retinal degeneration B alpha 3 antibody
      see all

    Images

    • ab21197 at 5ug/ml staining NIR1 in human heart tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent antigen retrieval in steam with citrate buffer (pH 6.0). The AP-staining procedure was used for detection.

    References

    ab21197 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab21197.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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