Overview

  • Product nameNitrendipine
  • Description
    L-type Ca2+ channel blocker
  • Biological descriptionL-type Ca2+ channel blocker. Antihypertensive in vivo.
  • Purity> 98%

Properties

    Applications

    Our Abpromise guarantee covers the use of ab120139 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    Nitrendipine images

    • ab2770 staining aryl hydrocarbon receptor in MDA-MB-231 cells treated with nitrendipine (ab120139), by ICC/IF. Increase in aryl hydrocarbon receptor expression correlates with increased concentration of nitrendipine, as described in literature.
      The cells were incubated at 37°C for 6h in media containing different concentrations of ab120139 (nitrendipine) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2770 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    References for Nitrendipine (ab120139)

    This product has been referenced in:
    • McCarthy RT & Fry HK Nitrendipine block of calcium channel currents in vascular smooth muscle and adrenal glomerulosa cells. J Cardiovasc Pharmacol 12 Suppl 4:S98-101 (1988). Read more (PubMed: 2468885) »
    • Weiland GA & Oswald RE The mechanism of binding of dihydropyridine calcium channel blockers to rat brain membranes. J Biol Chem 260:8456-64 (1985). Read more (PubMed: 3159733) »
    • Stoepel K  et al. Pharmacological studies of the antihypertensive effect of nitrendipine. Arzneimittelforschung 31:2056-61 (1981). Read more (PubMed: 7199297) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"