Overview

  • Product nameAnti-NK1.1 antibody [PK136] (FITC)
    See all NK1.1 primary antibodies
  • Description
    Mouse monoclonal [PK136] to NK1.1 (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • SpecificityThis antibody is specific to Mouse NK1.1 alloantigen, Mr 80-85 kDa (39 kDa under reducing conditions).
  • Tested applicationsSuitable for: Celluar Activation, Flow Cyt, IPmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    CD spleen and bone marrow cells enriched for NK1+ cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab25026 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Celluar Activation
Flow Cyt
IP
  • Application notesFlow Cyt: Use 1µg for 106 cells.
    IP: Use at an assay dependent dilution.
    In vitro complement dependent cytotoxicity assays.
    In vivo depletion and in vitro activation of NK1.1 cells and in vitro redirected lysis.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production.
    • Tissue specificityExpressed in natural killer cells.
    • Sequence similaritiesContains 1 C-type lectin domain.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD161 antigen like family member C antibody
      • CD161 antigen-like family member C antibody
      • CD161c antibody
      • Killer cell lectin-like receptor subfamily B member 1C antibody
      • Klrb1c antibody
      • Klrb1f antibody
      • KLRBC_MOUSE antibody
      • Ly-55c antibody
      • Ly55c antibody
      • Lymphocyte antigen 55c antibody
      • Lymphocyte antigen 59 antibody
      • Natural killer cell surface protein P1-40 antibody
      • NK1.1 antibody
      • NKR P1.9 antibody
      • NKR P1C antibody
      • NKR-P1 40 antibody
      • NKR-P1.9 antibody
      • NKR-P1C antibody
      • NKRP1 antibody
      see all

    Anti-NK1.1 antibody [PK136] (FITC) images

    • Flow Cytometry analysis of C57BL/6 mouse splenocytes labeling NK1.1 with ab25026 at 1 μg/106 cells dilution. A Rat Anti-Mouse CD49b-PE was used as the secondary antibody.

    References for Anti-NK1.1 antibody [PK136] (FITC) (ab25026)

    This product has been referenced in:
    • McAllister CS  et al. TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo. J Immunol 190:418-27 (2013). ICC/IF . Read more (PubMed: 23209324) »
    • Karlhofer FM & Yokoyama WM Stimulation of murine natural killer (NK) cells by a monoclonal antibody specific for the NK1.1 antigen. IL-2-activated NK cells possess additional specific stimulation pathways. J Immunol 146:3662-73 (1991). Read more (PubMed: 2026886) »

    See all 5 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"