The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-NKG2D antibody (ab36136)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Killer cell lectin like receptor subfamily K member 1
Killer cell lectin-like receptor subfamily K member 1
NK cell receptor D
NK lectin-like receptor
NKG2 D activating NK receptor
NKG2 D type II integral membrane protein
NKG2-D type II integral membrane protein
NKG2-D-activating NK receptor
FunctionReceptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.
Tissue specificityNatural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer dendritic cells (IKDCs).