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Product name
NKH 477 (Colforsin daropate)
Description
Water-soluble analogue of forskolin ab120058, an adenylyl cyclase activator
Alternative names
- Colforsin daropate hydrochloride
Biological description
Water-soluble adenylyl cyclase activator
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldod
Molecular Weight
546.10
Chemical structure
Molecular formula
C27H43NO8.HCl
CAS Number
138605-00-2
Solubility
Soluble in water to 25 mM
PubChem identifier
0
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Obesity >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Hypertension >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Heart disease >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Diabetes >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Cancer >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Pharmacology >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Pharmacology >> Enzymes >> Cyclase >> Adenylyl cyclase >> Activators
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Product Range >> Just Add Water
References for NKH 477 (Colforsin daropate) (ab120190)
This product has been referenced in:
- Morinobu S et al. Stimulation of adenylyl cyclase and induction of brain-derived neurotrophic factor and TrkB mRNA by NKH477, a novel and potent forskolin derivative. J Neurochem 72:2198-205 (1999).Read more (PubMed: 10217303) »
- Satake K et al. Relaxant effects of NKH477, a new water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: the role of Ca2+-activated K+ channels. Br J Pharmacol 123:753-61 (1998).Read more (PubMed: 9517396) »
See all 3 publications for this product
Publishing research using ab120190? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"