Overview

  • Product nameAnti-NKIRAS2 antibody
    See all NKIRAS2 primary antibodies
  • Description
    Mouse monoclonal to NKIRAS2
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-192 of Human NKIRAS2

Properties

Applications

Our Abpromise guarantee covers the use of ab57303 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAtypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
    • Tissue specificityWidely expressed.
    • Sequence similaritiesBelongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
    • DomainIn contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZP434N1526 antibody
      • I kappa B interacting Ras like protein 2 antibody
      • I-kappa-B-interacting Ras-like protein 2 antibody
      • Kappa B Ras protein 2 antibody
      • Kappa B-Ras protein 2 antibody
      • KappaB Ras2 antibody
      • KappaB-Ras2 antibody
      • KBRAS 2 antibody
      • KBRAS2 antibody
      • KBRS2_HUMAN antibody
      • MGC74742 antibody
      • NF kappa B inhibitor interacting Ras like protein 2 antibody
      • NF-kappa-B inhibitor-interacting Ras-like protein 2 antibody
      • NFKB inhibitor interacting Ras like 2 antibody
      • NFKB inhibitor interacting Ras like protein 2 antibody
      • NKIRAS 2 antibody
      • NKIRAS2 antibody
      see all

    Anti-NKIRAS2 antibody images

    • NKIRAS2 antibody (ab57303) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human tonsil.


    • Predicted band size : 22 kDa
      NKIRAS2 antibody (ab57303) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-NKIRAS2 antibody (ab57303)

    ab57303 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"