Overview

  • Product name
  • Description
    Rabbit polyclonal to Nkx3.1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to an N-terminal region of human Nkx3.1. The amino acid sequence is not available.

  • Positive control
    • Prostate carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab41856 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
  • Tissue specificity
    Highly expressed in the prostate and, at a lower level, in the testis.
  • Sequence similarities
    Belongs to the NK-3 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Post-translational
    modifications
    Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • BAPX 2 antibody
    • BAPX2 antibody
    • Homeobox protein NK-3 homolog A antibody
    • Homeobox protein Nkx 3.1 antibody
    • Homeobox protein Nkx-3.1 antibody
    • Homeobox protein Nkx3.1 antibody
    • NK homeobox (Drosophila) family 3 A antibody
    • NK homeobox family 3 A antibody
    • NK homeobox, family 3, member A antibody
    • NK3 homeobox 1 antibody
    • NK3 transcription factor homolog A antibody
    • NK3 transcription factor related locus 1 antibody
    • NKX 3 antibody
    • Nkx 3.1 antibody
    • NKX 3A antibody
    • NKX3 1 antibody
    • NKX3 antibody
    • Nkx3-1 antibody
    • NKX3.1 antibody
    • Nkx3.1, mouse, homolog of antibody
    • NKX31_HUMAN antibody
    • NKX3A antibody
    see all

Images

  • This image shows human prostate stained with ab41856 at 1/25 dilution.

References

ab41856 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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