Overview

  • Product nameAnti-nkx6.1 antibody
    See all nkx6.1 primary antibodies
  • Description
    Rabbit polyclonal to nkx6.1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Cow, Dog, Pig, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 2 - 51 (LAVGAMEGTR QSAFLLSSPP LAALHSMAEM KTPLYPAAYP PLPAGPPSSS) of Human nkx6.1 (NP_006159).

  • Positive control
    • Human fetal small intestine lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab90706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionTranscription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.
  • Tissue specificityPancreatic beta cells.
  • Sequence similaritiesContains 1 homeobox DNA-binding domain.
  • DomainThe C-terminal domain contributes to sequence-specific DNA-binding.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Homeobox protein NK-6 homolog A antibody
    • Homeobox protein Nkx-6.1 antibody
    • NK homeo box, family 6, member A antibody
    • NK homeobox (Drosophila), family 6, A antibody
    • NK homeobox, family 6, A antibody
    • NK6 homeobox 1 antibody
    • NK6 transcription factor homolog A antibody
    • NK6 transcription factor related, locus 1 antibody
    • NK6 transcription factor related, locus 1 (Drosophila) antibody
    • NKX6-1 antibody
    • NKX6.1 antibody
    • NKX61 antibody
    • NKX61_HUMAN antibody
    • NKX6A antibody
    see all

Anti-nkx6.1 antibody images

  • Anti-nkx6.1 antibody (ab90706) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal small intestine lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 38 kDa

References for Anti-nkx6.1 antibody (ab90706)

This product has been referenced in:
  • Wheeler E  et al. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. Nat Genet 45:513-7 (2013). Human . Read more (PubMed: 23563609) »

See 1 Publication for this product

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