Overview

  • Product nameAnti-NLK antibody
    See all NLK primary antibodies
  • Description
    Rabbit polyclonal to NLK
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C-terminal amino acids 407-436 of Human NLK (NP_032728.3)

  • Positive control
    • MCF7 cell line and Mouse lung tissue lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab116715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 58 kDa.

Target

  • FunctionRole in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Dually phosphorylated on Thr-303 and Tyr-305, which activates the enzyme.
  • Cellular localizationNucleus. Cytoplasm. Predominantly nuclear. A smaller fraction is cytoplasmic.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp761G1211 antibody
    • FLJ21033 antibody
    • LAK1 antibody
    • Nemo like kinase antibody
    • Nemo-like kinase antibody
    • Nlk antibody
    • NLK_HUMAN antibody
    • Protein LAK1 antibody
    • Serine/threonine protein kinase NLK antibody
    • Serine/threonine-protein kinase NLK antibody
    see all

Anti-NLK antibody images

  • Anti-NLK antibody (ab116715) at 1/100 dilution + MCF7 cell line lysate at 35 µg

    Predicted band size : 58 kDa
  • Anti-NLK antibody (ab116715) at 1/100 dilution + Mouse lung tissue lysate at 35 µg

    Predicted band size : 58 kDa

References for Anti-NLK antibody (ab116715)

ab116715 has not yet been referenced specifically in any publications.

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