The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 204 kDa.
Use at an assay dependent concentration.
Use a concentration of 5 µg/ml.
FunctionProbable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
Tissue specificityExpressed in spleen, thymus, lung, brain, tonsil, heart and prostate.
Sequence similaritiesBelongs to the NLRP family. Contains 26 LRR (leucine-rich) repeats. Contains 1 NACHT domain.